IFI-C · Hydroxycitronellal

Specimen SS-F-CLB-775 // COOL BURN · IFI-C

Hydroxycitronellal II-IV-A

Lavandula angustifolia

Lavender

Tier IIHydroxycitronellal

Target Trait

1.38×

fold-change

hydroxycitronellal accumulation fold-change

Technical Specifications

SKU

SS-F-CLB-775

Genomic Edits

4

GC Content

45.4%

Construct Length

2,757 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro T7/SP6 cell-free

Host Strain

Cell-free

Receptor Target

TRPM8

IFI Score

138

Pathway Edits

  • CES1 (citronellol synthase 1) codon-optimized overexpression in Lavandula angustifolia
  • COX1 (citronellol oxidase 1) precision upregulation for hydroxycitronellal formation
  • ADH1 (alcohol dehydrogenase 1) loss-of-function to prevent citronellal reduction back to citronellol
  • GPPS (geranyl pyrophosphate synthase) upregulation for monoterpene precursor maintenance

Key Interventions

Hydroxycitronellal terpene aldehyde overproduction via CES1/COX1 sequential pathway upregulationADH1 suppression to prevent competing citronellal/citronellol equilibriumTRPM8 activation with distinctive muguet-floral cooling aldehyde character

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
138
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Floral-cooling ingredient development, muguet fragrance ingredient sourcing, non-menthol TRPM8 agonist formulation, and cosmetic fragrance-cooling applications requiring hydroxycitronellal from botanical source.

License

$699 · Tier II License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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