IFI-C · Neomenthol

Specimen SS-F-CLB-576 // COOL BURN · IFI-C

Neomenthol II-IV-B

Mentha × piperita

Peppermint

Tier IINeomenthol

Target Trait

1.82×

fold-change

neomenthol accumulation fold-change

Technical Specifications

SKU

SS-F-CLB-576

Genomic Edits

5

GC Content

47.3%

Construct Length

3,154 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro T7/SP6 cell-free

Host Strain

Cell-free

Receptor Target

TRPM8

IFI Score

182

Pathway Edits

  • MNR-alt (menthone reductase alternative stereoisomer variant) precision editing for neomenthol specificity
  • PS (pulegone synthase) upregulation for precursor substrate maintenance
  • MNPQ-alt (menthone 9-reductase alternative variant) stereoselective co-upregulation
  • L-menthol oxidase suppression cassette to prevent competing menthol accumulation

Key Interventions

Neomenthol stereoisomeric TRPM8 variant overproduction via MNR-alt/MNPQ-alt engineeringStereoselective menthone reduction bias toward neomenthol over L-menthol via variant integrationTRPM8 receptor activation with distinct milder-cooling neomenthol sensory profile

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
182
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Mild cooling ingredient development, pharmaceutical flavor masking applications, neomenthol reference standard production, and confectionery applications requiring softer cooling character.

License

$749 · Tier II License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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