IFI-C · R-Carvone Cooling

Specimen SS-F-CLB-272 // COOL BURN · IFI-C

R-Carvone Cooling IV-IV-B

Mentha spicata

Spearmint

Tier IVR-Carvone Cooling

Target Trait

3.39×

fold-change

R-carvone accumulation fold-change

Technical Specifications

SKU

SS-F-CLB-272

Genomic Edits

7

GC Content

46.2%

Construct Length

4,008 bp

Promoter System

T7/SP6 cell-free

Expression System

In-vitro T7/SP6 cell-free

Host Strain

Cell-free

Receptor Target

TRPM8

IFI Score

339

Pathway Edits

  • CPS (carveol phosphate synthase) tissue-specific overexpression construct
  • L6H (limonene-6-hydroxylase) stereoselective variant for R-carvone branch flux
  • CS (carvone synthase variant) codon-optimized coding sequence replacement
  • SDR1 (short-chain dehydrogenase/reductase 1) gain-of-function edit for oxidation step
  • Spearmint trichome-specific promoter swap for pathway gene localization

Key Interventions

R-carvone overproduction via CPS/CS pathway co-upregulation in Mentha spicataStereospecific R-enantiomer accumulation through SDR1 variant integrationTRPM8 cooling activation enhancement via elevated R-carvone concentration

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
339
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

High-yield R-carvone crop platform development, industrial flavor ingredient supply, clinical sensory research applications, and novel spearmint-dominant cooling ingredient programs.

License

$4049 · Tier IV License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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