IFI-C · R-Carvone Cooling

Specimen SS-F-CLB-260 // COOL BURN · IFI-C

R-Carvone Cooling III-BL-B

Mentha spicata

Spearmint

Tier IIIR-Carvone Cooling

Target Trait

2.76×

fold-change

R-carvone accumulation fold-change

Technical Specifications

SKU

SS-F-CLB-260

Genomic Edits

6

GC Content

46.5%

Construct Length

3,593 bp

Promoter System

CaMV 35S / Ubiquitin

Expression System

Biolistic transformation

Host Strain

Particle Gun

Receptor Target

TRPM8

IFI Score

276

Pathway Edits

  • CPS (carveol phosphate synthase) tissue-specific overexpression construct
  • L6H (limonene-6-hydroxylase) stereoselective variant for R-carvone branch flux
  • CS (carvone synthase variant) codon-optimized coding sequence replacement
  • SDR1 (short-chain dehydrogenase/reductase 1) gain-of-function edit for oxidation step
  • Spearmint trichome-specific promoter swap for pathway gene localization

Key Interventions

R-carvone overproduction via CPS/CS pathway co-upregulation in Mentha spicataStereospecific R-enantiomer accumulation through SDR1 variant integrationTRPM8 cooling activation enhancement via elevated R-carvone concentration

IFI Subscale Profile

IFI Profile

IFI-S
—
IFI-U
—
IFI-B
—
IFI-K
—
IFI-C
276
IFI-P
—
IFI-A
—
IFI-F
—

Use Case

Premium spearmint oil production, R-carvone pharmaceutical ingredient supply, functional beverage cooling enhancement, and cosmetic fragrance cooling ingredient development.

License

$1549 · Tier III License

Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.

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