Specimen SS-F-BTR-870 // ZERO-BITTER · IFI-B
Prenylflavonoid · T4 Protoplast-B
Humulus lupulus
Hops
Target Trait
65%
% reduction
Isoxanthohumol/8-PN reduction
Technical Specifications
SKU
SS-F-BTR-870
Genomic Edits
6
GC Content
49.3%
Construct Length
3,594 bp
Promoter System
35S CaMV / RbcS
Expression System
PEG-mediated protoplast transfection
Host Strain
Isolated leaf mesophyll protoplasts
Receptor Target
TAS2R38 (suppression)
IFI Score
65
Pathway Edits
- OMT1 O-methyltransferase RNAi reduces xanthohumol-to-isoxanthohumol Cope rearrangement substrate availability
- PrenylT prenyltransferase RNAi limits prenylation of naringenin chalcone at the C-8 position
- CHS2 chalcone synthase isoform modification reduces xanthohumol precursor pool from phloroglucyl-CoA
Key Interventions
IFI Subscale Profile
IFI Profile
Use Case
Tier IV Humulus lupulus lines for brewery applications targeting soft bitterness profiles, cosmetic and nutraceutical hop extracts requiring controlled 8-PN content, and non-alcoholic hop-flavored beverages where prenylflavonoid bitterness would detract from consumer palatability.
License
$4049 · Tier IV License
Includes full construct sequence, CRISPR guide designs, pathway edit specifications, flux balance analysis, and IFI validation data.
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